Toremifene

Toremifene is a prescription medication used to treat certain types of breast cancer in post-menopausal women.

Toremifene belongs to a group of drugs called nonsteroidal antiestrogens. It works by blocking the activity of estrogen in the breast which stops the cancer from growing.

This medication comes in tablet form and is taken once a day, with or without food. 

Toremifene is a prescription medication used to treat certain types of breast cancer in post-menopausal women.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. 

Take toremifene exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The recommended daily dosage of toremifene is 60 mg.

WARNING: QT PROLONGATION

Toremifene has been shown to prolong the QTc interval in a dose- and concentration-related manner. Prolongation of the QT interval can result in a type of ventricular tachycardia called Torsade de pointes, which may result in syncope, seizure, and/or death. Toremifene should not be prescribed to patients with congenital/acquired QT prolongation, uncorrected hypokalemia or uncorrected hypomagnesemia. Drugs known to prolong the QT interval and strong CYP3A4 inhibitors should be avoided.

Do not use toremifene if you are allergic to any of its ingredients.

Do not use toremifene if you have long QT syndrome or low blood potassium or magnesium levels.

Toremifene may make you dizzy. Do not drive or operate heavy machinery or perform any activity that requires alertness until you know how toremifene affects you.

Toremifene may cause a serious heart condition called QT prolongation (irregular heart rhythm). Tell your doctor right away if you have any of the following symptoms:

• fast, pounding, or irregular heartbeat
• fainting spell
• seizures

This medication can lower the number of white blood cells and platelets in your blood, increasing the risk of getting an infection and bleeding. Avoid people with infections. Tell your doctor right away if you have signs of infection including:

• fever
• chills
• sore throat
• cough

Tell your doctor if you experience unusual bleeding or bruising, or blood in the urine or stools.

You may experience bleeding from the vagina when you first start using this medication. If bleeding continues, notify your doctor.

Some common side effects of toremifene include:

• sweating
• hot flashes
• nausea
• dizziness
• dry eyes

If any of these side effects are bothersome or do not go away, notify your doctor right away.

Tell your doctor right away if you experience any of these severe side effects:

• bone, joint, or muscle pain or swelling
• constipation
• mental (mood) changes (such as depression or hallucinations)
• difficulty walking or decreased coordination
• swelling ankles, feet, lower legs, hands, face, mouth, lips, tongue, or throat
• rash or itching
• difficulty breathing
• unusual tiredness
• vision changes (such as blurred vision, eye pain)
• fever, chills, or sore throat
• changes in menstrual period
• unusual vaginal bleeding or discharge
• easy bleeding or bruising
• severe nausea and vomiting
• severe stomach pain
• dark urine
• yellowing eyes or skin
• numbness of arm or leg
• weakness on one side of the body
• chest pain or jaw pain
• irregular heartbeat
• fainting
• sudden, severe headache

This is not a complete list of toremifene side effects. Ask your doctor or pharmacist for more information.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• amitriptyline (Elavil)
• antifungals such as ketoconazole (Nizoral), itraconazole (Sporanox), or voriconazole (Vfend)
• clarithromycin (Biaxin, in Prevpac)
• erythromycin (E.E.S., E-Mycin, Erythrocin)
• granisetron (Kytril)
• haloperidol (Haldol)
• certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase)
• certain medications for irregular heartbeat such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), ibutilide (Corvert), procainamide (Procanbid, Pronestyl), quinidine, and sotalol (Betapace, Betapace AF)
• levofloxacin (Levaquin)
• nefazodone
• ofloxacin
• ondansetron (Zofran)
• telithromycin (Ketek)
• thioridazine
• venlafaxine (Effexor)
• anticoagulants (''blood thinners'') such as warfarin (Coumadin)
• carbamazepine (Epitol, Equetro, Tegretol)
• cimetidine (Tagamet)
• clonazepam (Klonopin)
• dexamethasone (Decadron, Dexone)
• diltiazem (Cardizem, Dilacor, Tiazac, others)
• diuretics ('water pills') such as hydrochlorothiazide
• fluvoxamine
• phenobarbital
• phenytoin (Dilantin, Phenytek)
• rifabutin (Mycobutin)
• rifampin (Rifadin, Rimactane)
• verapamil (Calan, Covera, Isoptin, Verelan)
• St. John's wort

This is not a complete list of toremifene drug interactions. Ask your doctor or pharmacist for more information.

Toremifene is approved for use in women who have been through menopause. If you have not been through menopause you should avoid pregnancy during toremifene treatment. This medication may harm the unborn baby.

Talk to your doctor about the use of birth control while receiving this medication.

Tell your doctor right away if you become pregnant during toremifene treatments.

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if toremifene is excreted in human breast milk or if it will harm your nursing baby.

Your doctor will likely order blood tests to monitor for harmful side effects.

Grapefruit and grapefruit juice may interact with toremifene and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Toremifene may make you dizzy. Do not drive or operate heavy machinery or perform any activity that requires alertness until you know how toremifene affects you.