Remeron SolTab

Remeron SolTab is a prescription medication used to treat depression. Remeron SolTab belongs to a group of drugs called antidepressants, which may help maintain mental balance by blocking certain receptors in the brain.

This medication comes in an orally disintegrating tablet which dissolves on the tongue with no need for water. It is taken once a day in the evening, with or without food. Do not chew, divide, or break Remeron SolTab.

Common side effects include increased appetite, dry mouth, and constipation. Remeron SolTab can cause drowsiness and dizziness. Do not drive or operate machinery until you know how this medication will affect you.

Remeron SolTab is a prescription medicine used to treat depression. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

• how you respond to this medication
• your age
• your renal function
• your hepatic function

The recommended starting dose for Remeron SolTab is 15 mg/day, administered in a single dose, in the evening prior to sleep.

The recommended dose range of Remeron SolTab for the treatment of depression is 15 to 45 mg/day.

Suicidality and Antidepressant Drugs

Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of Remeron SolTab or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Remeron SolTab is not approved for use in pediatric patients.

Remeron SolTab and other antidepressant medicines may cause serious side effects, including:

• Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment or when the dose is changed.
• Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions.
• Watch for these changes and call your healthcare provider right away if you notice:
  • New or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe.
  • Pay particular attention to such changes when Remeron SolTab is started or when the dose is changed.
  
  Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms.
  Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency, especially if they are new, worse, or worry you:
  • attempts to commit suicide
  • acting on dangerous impulses
  • acting aggressive or violent
  • thoughts about suicide or dying
  • new or worse depression
  • new or worse anxiety or panic attacks
  • feeling agitated, restless, angry or irritable
  • trouble sleeping
  • an increase in activity or talking more than what is normal for you
  • other unusual changes in behavior or mood

Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency. Remeron SolTab may be associated with these serious side effects:

• trouble breathing, swelling of the face, tongue, eyes or mouth

• greatly increased energy
• severe trouble sleeping
• racing thoughts
• reckless behavior
• unusually grand ideas
• excessive happiness or irritability
• talking more or faster than usual

• agitation, hallucinations, coma or other changes in mental status
• coordination problems or muscle twitching (overactive reflexes)
• racing heartbeat, high or low blood pressure
• sweating or fever
• nausea, vomiting, or diarrhea
• muscle rigidity

• headache
• weakness or feeling unsteady
• confusion, problems concentrating or thinking or memory problems

• severe rash with skin swelling (including on the palms of the hands and soles of the feet)
• painful reddening of the skin and/or blisters/ulcers on the body or in the mouth

• rash, itchy welts (hives) or blisters, alone or with fever or joint pain

Do not stop Remeron SolTab without first talking to your healthcare provider. Stopping Remeron SolTab too quickly may cause potentially serious symptoms including:

• dizziness
• abnormal dreams
• agitation
• anxiety
• fatigue
• confusion
• headache
• shaking
• tingling sensation
• nausea, vomiting
• sweating

Do not take Remeron SolTab if you:

• are allergic to Remeron SolTab or any of the ingredients in it. 
• take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid. It is recommended that Remeron SolTab not be used in combination with an MAOI within 14 days of initiating or discontinuing therapy with an MAOI. People who take Remeron SolTab close in time to an MAOI may have serious or even life-threatening side effects. Get medical help right away if you have any of these symptoms:
  • high fever
  • uncontrolled muscle spasms
  • stiff muscles
  • rapid changes in heart rate or blood pressure
  • confusion
  • loss of consciousness (pass out)

Remeron SolTab may cause serious side effects, including all of those described in the section entitled "Drug Precautions".

Common possible side effects in people who take Remeron SolTab include:

• sleepiness
• increased appetite, weight gain
• dry mouth
• constipation
• dizziness
• abnormal dreams

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Remeron SolTab. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your healthcare provider about all the medicines that you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. 

Especially tell your doctor if you take:

• monoamine oxidase inhibitors (MAOI) such as:
  • isocarboxazid (Marplan)
  • phenelzine (Nardil)
  • selegiline (Eldepryl, Emsam, Zelapar)
  • tranylcypromine (Parnate)
• tricyclic antidepressants such asL
  • amitriptyline (Elavil)
  • amoxapine (Asendin)
  • clomipramine (Anafranil)
  • desipramine (Norpramin)
  • nortriptyline (Aventyl, Pamelor)
• ketoconazole (Nizoral)
• buspirone (Buspar)
• carbamazepine (Carbatrol, Equetro, Tegretol)
• cimetidine (Tagamet)
• diazepam (Valium)
• lithium (Lithobid)
• 'Triptan' medications such as:
  • almotriptan (Axert)
  • eletriptan (Relpax)
  • frovatriptan (Frova)
  • naratriptan (Amerge)
  • rizatriptan (Maxalt)
  • sumatriptan (Imitrex)
  • zolmitriptan (Zomig)
• phenytoin (Dilantin)
• rifampicin
• rifampin (Rimactane, Rifadin)
• selective serotonin reuptake inhibitors (SSRIs) such as:
  • citalopram (Celexa)
  • escitalopram (Lexapro)
  • fluoxetine (Prozac, Sarafem)
  • fluvoxamine (Luvox)
  • paroxetine (Paxil, Pexeva)
  • sertraline (Zoloft)
• selective serotonin and norepinephrine reuptake inhibitors (SNRIs) such as:
  • desvenlafaxine (Pristiq)
  • duloxetine (Cymbalta)
  • venlafaxine (Effexor)
• tramadol (Ultram)
• tryptophan or St. John's Wort

This is not a complete list of Remeron SolTab drug interactions.

Your healthcare provider or pharmacist can tell you if it is safe to take Remeron SolTab with your other medicines. Do not start or stop any medicine while taking Remeron SolTab without talking to your healthcare provider first.

Tell your healthcare provider if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Remeron SolTab falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans, though. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Some Remeron SolTab may pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking Remeron SolTab.

Mirtazapine can cause an increase in appetite and cause weight gain.

Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment or when the dose is changed.

Watch for these changes and call your healthcare provider right away if you notice:

• New or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe.
• Pay particular attention to such changes when mirtazapine is started or when the dose is changed.

Do not stop mirtazapine without first talking to your healthcare provider. Stopping mirtazapine too quickly may cause potentially serious symptoms.

It is common for antidepressant medicines such as mirtazapine to take up to a few weeks before you start to feel better. Do not stop taking mirtazapine if you do not feel results right away.