Mirapex ER

Mirapex ER is a prescription medication used to treat Parkinson's Disease. Mirapex ER belongs to a group of drugs called dopamine agonists which work by binding to dopamine receptors in the brain, helping to control movement.

Mirapex ER comes as an extended release tablet and is taken once a day, with or without food. Swallow extended release tablet whole. Do not chew, crush, or divide extended release tablets.

Common side effects include nausea, dizziness, and drowsiness. Do not drive or operate heavy machinery until you know how this medication affects you.

Mirapex ER tablets is a prescription medicine used to treat signs and symptoms of Parkinson's disease.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Take Mirapex ER exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. Mirapex ER comes as an extended release tablet to take by mouth.

Mirapex ER tablets when treating Parkinson's disease, is usually taken once a day.

The recommended starting dose is 0.375 mg given once daily. The maximum recommended dose is 4.5 mg per day.

Mirapex ER may cause serious side effects, including:

• falling asleep during normal daily activities. Mirapex ER may cause you to fall asleep while you are doing daily activities such as driving, talking with other people, or eating.
  • Some people taking the medicine in Mirapex ER have had car accidents because they fell asleep while driving.
  • Some patients did not feel sleepy before they fell asleep while driving. You could fall asleep without any warning.
    Tell your doctor right away if you fall asleep while you are doing activities such as talking, eating, driving, or if you feel sleepier than normal for you.
• low blood pressure when you sit or stand up quickly. You may have:
  • dizziness
  • nausea
  • fainting
  • sweating
    Sit and stand up slowly after you have been sitting or lying down.
• unusual urges. Some people who take certain medicines to treat Parkinson’s disease, including Mirapex ER, have reported problems, such as gambling, compulsive eating, compulsive buying, and increased sex drive.
  If you or your family members notice that you are developing unusual urges or behaviors, talk to your doctor.
• seeing visions, hearing sounds or feeling sensations that are not real (hallucinations). Your chance of having hallucinations is higher if you are elderly (age 65 or older).
  If you have hallucinations, talk with your doctor right away.
• uncontrolled sudden movements (dyskinesia). If you have new dyskinesia or your existing dyskinesia gets worse tell your doctor.
• skin cancer (melanoma). Some people with Parkinson’s disease may have a higher chance of having melanoma than people who do not have Parkinson’s disease. It is not known if the chance of having melanoma is higher because of the medicines to treat Parkinson’s disease, like Mirapex ER, or from the Parkinson’s disease. People who take Mirapex ER should have regular skin examinations to check for melanoma.

Do not drink alcohol while taking Mirapex ER. It can increase your chance of having serious side effects. 

Do not drive a car, operate a machine, or do other dangerous activities until you know how Mirapex ER affects you. Sleepiness caused by Mirapex ER can happen as late as 1 year after you start your treatment.

Mirapex ER may cause serious side effects. See "Drug Precautions" section.

The most common side effects in people taking Mirapex ER for Parkinson’s disease are nausea, dizziness, sleepiness, constipation, hallucinations, insomnia, muscle weakness, confusion, and abnormal movements.

Tell your doctor about all the medicines you take including prescription and nonprescription medications, vitamins, nutritional supplements and herbal products. Be sure to mention any of the following:

• amantadine (Symadine, Symmetrel)
• antidepressants
• antihistamines
• cimetidine (Tagamet)
• diltiazem (Cardiazem, Dilacor XR)
• levodopa (Larodopa, Dopar, in Sinemet)
• medications for allergies, anxiety, mental illness, nausea, and seizure
• metoclopramide (Reglan)
• quinidine
• quinine
• ranitidine (Zantac, Zantac 75)
• sedatives
• sleeping pills
• tranquilizers
• triamterene (Dyrenium, in Dyazide, in Maxzide)
• and verapamil (Isoptin, Calan, Verelan, and others)

This is not a complete list of Mirapex ER drug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Mirapex ER falls into category C. There are no well-controlled studies in pregnant women. Mirapex ER should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if Mirapex ER is excreted in human breast milk or if it will harm your nursing baby.

Do not drink alcohol while taking pramipexole. It can increase your chance of having serious side effects.

Pramipexole can cause drowsiness. Sleepiness caused by pramipexole can happen as late as 1 year after you start your treatment.

Pramipexole can be taken with or without food. Taking pramipexole with food may lower your chances of getting nausea.

Be sure to tell your doctor right away if you stop taking pramipexole for any reason. Do not start taking pramipexole again before speaking with your doctor. If you have Parkinson’s disease and are stopping pramipexole, you should stop pramipexole slowly over 7 days.