Lamictal

Lamictal is a prescription medication used to treat epilepsy and bipolar disorder. Lamictal belongs to a group of drugs called anticonvulsants, which decrease abnormal brain activity.

Lamictal is available as a tablet to be taken by mouth one to three times a day.

Common side effects of Lamictal include dizziness, headache, sleepiness, and tremor.

Lamictal is a prescription medicine used together with other medicines to treat certain types of seizures in people 2 years or older.

Lamictal is also used for the treatment of bipolar disorder in people 18 years or older who have been treated for mood episodes with other medicine.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Take Lamictal exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you. Often patients begin taking a low dose for the first 2 weeks and that is followed by a dose increase for weeks 3 and 4. Then from week 5 on, a dose increase every 1 to 2 weeks is added until the best dose is achieved. 

WARNING: SERIOUS SKIN RASHES                                                           

Lamictal can cause serious rashes requiring hospitalization and discontinuation of treatment. The incidence of these rashes, which have included Stevens-Johnson syndrome, is approximately 0.8% (8 per 1,000) in pediatric patients (2 to 16 years of age) receiving Lamictal as adjunctive therapy for epilepsy and 0.3% (3 per 1,000) in adults on adjunctive therapy for epilepsy. In clinical trials of bipolar and other mood disorders, the rate of serious rash was 0.08% (0.8 per 1,000) in adult patients receiving Lamictal as initial monotherapy and 0.13% (1.3 per 1,000) in adult patients receiving Lamictal as adjunctive therapy. In a prospectively followed cohort of 1,983 pediatric patients (2 to 16 years of age) with epilepsy taking adjunctive Lamictal, there was 1 rash-related death. In worldwide postmarketing experience, rare cases of toxic epidermal necrolysis and/or rash-related death have been reported in adult and pediatric patients, but their numbers are too few to permit a precise estimate of the rate.

Other than age, there are as yet no factors identified that are known to predict the risk of occurrence or the severity of rash caused by Lamictal. There are suggestions, yet to be proven, that the risk of rash may also be increased by (1) coadministration of Lamictal with valproate (includes valproic acid and divalproex sodium), (2) exceeding the recommended initial dose of Lamictal, or (3) exceeding the recommended dose escalation for Lamictal. However, cases have occurred in the absence of these factors.

Nearly all cases of life-threatening rashes caused by Lamictal have occurred within 2 to 8 weeks of treatment initiation. However, isolated cases have occurred after prolonged treatment (e.g., 6 months). Accordingly, duration of therapy cannot be relied upon as means to predict the potential risk heralded by the first appearance of a rash.

Although benign rashes are also caused by Lamictal, it is not possible to predict reliably which rashes will prove to be serious or life threatening. Accordingly, Lamictal should ordinarily be discontinued at the first sign of rash, unless the rash is clearly not drug related. Discontinuation of treatment may not prevent a rash from becoming life threatening or permanently disabling or disfiguring.

Lamictal can cause serious side effects such as:

Serious skin rash. Lamictal may cause a serious skin rash that may cause you to be hospitalized or even cause death.

There is no way to tell if a mild rash will become more serious. A serious skin rash can happen at any time during your treatment with Lamictal but is more likely to happen within the first 2 to 8 weeks of treatment. Children between 2 to 16 years of age have a higher chance of getting this serious skin rash while taking Lamictal.

The risk of getting a serious skin rash is higher if you:

• take Lamictal while taking valproate [Depakene (valproic acid) or Depakote (divalproex sodium)]
• take a higher starting dose of Lamictal than your doctor prescribed
• increase your dose of Lamictal faster than prescribed.

Call your doctor right away if you experience a skin rash, blistering or peeling of your skin, hives, or painful sores in your mouth or around your eyes. These symptoms may be the first signs of a serious skin reaction. A doctor should examine you to decide if you should continue taking Lamictal.

Immune system reaction called hemophagocytic lymphohistiocytosis (HLH). This can cause severe inflammation throughout the body and lead to hospitalization and death. Tell your doctor immediately if you notice any of the following symptoms: fever, rash, symptoms may include pain, tenderness, or unusual swelling over the liver area in the upper right belly, swollen lymph nodes, yellow skin or eyes, unusual bleeding, or nervous system problems (seizures, trouble walking, difficulty seeing, or other visual disturbances).

Serious blood problems or liver problems. Lamictal can also cause other types of allergic reactions or serious problems that may affect organs and other parts of your body like your liver or blood cells. You may or may not have a rash with these types of reactions. Call your doctor right away if you have any of these symptoms:

• fever
• frequent infections
• severe muscle pain
• swelling of your face, eyes, lips, or tongue
• swollen lymph glands
• unusual bruising or bleeding
• weakness, fatigue
• yellowing of your skin or the white part of your eyes

Suicidal thoughts or actions. Like other antiepileptic drugs, Lamictal may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.

Call a doctor right away if you have any of these symptoms, especially if they are new, worse, or worry you:

• thoughts about suicide or dying
• attempt to commit suicide
• new or worse depression
• new or worse anxiety
• feeling agitated or restless
• panic attacks
• trouble sleeping (insomnia)
• new or worse irritability
• acting aggressive, being angry, or violent
• acting on dangerous impulses
• an extreme increase in activity and talking (mania)
• other unusual changes in behavior or mood

Aseptic meningitis. Lamictal may rarely cause aseptic meningitis, a serious inflammation of the protective membrane that covers the brain and spinal cord. 

Meningitis has many causes other than Lamictal, which your doctor would check for if you developed meningitis while taking Lamictal.Call your doctor right away if you experience headache, fever, nausea/vomiting, stiff neck, rash, or unusual sensitivity to light. Other symptoms to look for include muscle pains, chills, confusion, and drowsiness. 

Patients prescribed Lamictal have sometimes been given the wrong medicine because many medicines have names similar to Lamictal, so always check that you receive Lamictal.

Do not drive a car or operate complex, hazardous machinery until you know how Lamictal affects you.

Do not stop taking Lamictal without talking to your doctor. Stopping Lamictal suddenly may cause serious problems including seizures that do not stop. Your doctor will help you to gradually decrease your dose.

Do not take Lamictal if you have had an allergic reaction to Lamictal or to any of the inactive ingredients in Lamictal. 

Serious side effects can happen with Lamictal. See Drug Precautions. 

Common side effects of Lamictal include:

• dizziness
• headache
• blurred or double vision
• lack of coordination
• sleepiness
• nausea, vomiting
• insomnia
• tremor
• rash
• fever
• abdominal pain
• back pain
• tiredness
• dry mouth

Tell your doctor about any side effect that bothers you or that does not go away. These are not all the possible side effects of Lamictal. For more information, ask your doctor or pharmacist.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Lamictal and other medicines may affect each other. Always check with your doctor before starting or stopping any medicines. Especially tell your doctor if you take:

• valproic acid (Depakene);
• divalproex (Depakote);
• methotrexate (Rheumatrex, Trexall); other medications for seizures such as carbamazepine (Tegretol), oxcarbazepine (Trileptal), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin), and primidone (Mysoline);
• pyrimethamine (Daraprim);
• rifampin (Rifadin, Rimactane);
• trimethoprim (Proloprim);
• hormonal contraceptives (birth control pills, patches, rings, injections, implants, or intrauterine devices)
• hormone replacement therapy medicines (estrogens, progestins and combination medicines)

Tell your doctor if you are pregnant or plan to become pregnant. It is not known if Lamictal will harm your unborn baby.

Tell your doctor if you are breastfeeding or planning to breastfeed. Lamictal passes into breast milk and may cause side effects in a breastfed baby. If you breastfeed while taking Lamictal, watch your baby closely for trouble breathing, episodes of temporarily stopping breathing, sleepiness, or poor sucking. Call your baby’s healthcare provider right away if you see any of these problems. Talk to your healthcare provider about the best way to feed your baby if you take Lamictal. 

Lamotrigine may cause a serious skin rash that may cause you to be hospitalized or even cause death.

• There is no way to tell if a mild rash will become more serious.
• A serious skin rash can happen at any time during your treatment with lamotrigine, but is more likely to happen within the first 2 to 8 weeks of treatment.
• Children between 2 to 16 years of age have a higher chance of getting this serious skin rash while taking lamotrigine.

Do not start or stop taking birth control pills or other female hormonal medicine until you have talked with your doctor. Starting these medicines may lessen how well lamotrigine works.

You may not feel the full effect of lamotrigine for several weeks.