Eribulin

Eribulin is a prescription medication used to treat breast and soft tissue cancers. Eribulin belongs to a group of drugs called microtubule inhibitors, which stop the growth and spread of cancer cells.

This medication comes in an injectable form and is given into the vein (intravenously) by a healthcare provider on days 1 and 8 of a 21-day cycle.

Common side effects include weakness, tiredness, hair loss, and nausea.

Eribulin is a prescription medicine used to treat people with breast cancer that has spread to other parts of the body, and who have already received certain types of anticancer medicines after their breast cancer has spread. Eribulin is also used to treat liposarcoma (soft tissue cancer) that cannot be removed by surgery or is advanced (metastatic).

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Receive this medication exactly as prescribed by your doctor.

The dose your doctor recommends may be based on the following:

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your height
• your age
• your liver function

The recommended dose is 1.4 mg/m2 injected over 2 to 5 minutes on Days 1 and 8 of a 21-day cycle.

Your healthcare provider should do blood tests regularly to check your blood cell counts before you receive each dose of eribulin.

• Eribulin can cause a decrease in white blood cell count (neutropenia). This can make you more likely to get serious infections that could lead to death. You may need treatment in the hospital with antibiotic medicines.
• Call your healthcare provider right away if you develop any of these symptoms of infection while you are receiving eribulin:
  • fever (temperature above 100.5°F)
  • chills
  • cough
  • burning or pain when you urinate.
• Eribulin can cause numbness, tingling, or burning in your hands and feet (neuropathy). Tell your healthcare provider if you have any of these symptoms.
• Eribulin can cause changes in your heartbeat (called QTc prolongation). This can cause irregular heartbeats that may lead to death. Your healthcare provider will decide if you need heart monitoring (electrocardiogram or ECG), or blood tests during your treatment with eribulin to watch for this problem.

Eribulin may cause serious side effects. See "Eribulin Precautions" section.

The most common side effects of eribulin include:

• weakness or tiredness
• hair loss
• nausea
• constipation

Tell your healthcare provider about any side effect that bothers you or that does not go away.

These are not all the possible side effects of eribulin. For more information, ask your healthcare provider or pharmacist.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take other chemotherapy medicines as well as other QT-prolonging medications (a specific change in heart rhythm). 

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Eribulin falls into category D. There are no well done studies in pregnant women. In animal studies, pregnant animals were given this medication and had some babies born with problems. This medication is expected to cause fetal harm when administered to a pregnant woman. However, in some serious situations, the benefit of using this medication may be greater than the risk of harm to the baby.

Tell your healthcare provider if you are breastfeeding or planning to breastfeed. It is not known if eribulin passes into your breast milk. You and your healthcare provider should decide if you will take eribulin or breastfeed. You should not do both.

Your healthcare provider should do blood tests regularly to check your blood cell counts before you receive each dose of eribulin.

Your healthcare provider may need to decrease your dose or change how often you receive it, depending on your blood test results.

The most common side effects of eribulin include:

• weakness or tiredness
• hair loss
• nausea
• constipation

Call your healthcare provider right away if you develop any symptoms of infection.