Coagulation Factor X (Human)

Coagulation Factor X (Human) is a prescription medication used to help stop or prevent bleeding in those with hereditary Factor X deficiency, a rare, inherited bleeding disorder. 

It belongs to a group of drugs called blood coagulation factors. These work to activate substances in your blood to form clots and decrease bleeding episodes.

This medication is available as a powder for solution to be injected directly into the vein (IV) by a healthcare professional.

Common side effects of coagulation Factor X (human) include pain and redness at the injection site and fatigue.

Coagulation Factor X is a prescription medication used to help stop or prevent bleeding in adults and children (aged 12 years and above) with hereditary Factor X deficiency, a rare, inherited bleeding disorder. 

Coagulation Factor X can be used to control bleeding episodes. It can also be used to manage bleeding after surgery in patients with mild hereditary Factor X deficiency.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

The dosage and duration of treatment depend on the severity of the Factor X deficiency, on the location and extent of the bleeding and on the patient’s clinical condition.

Serious side effects have been reported with this medication including the following:

Allergic reactions. You can have an allergic reaction to coagulation Factor X. Stop treatment and call your healthcare provider right away if you have any of the following symptoms:

• difficulty breathing
• chest tightness
• swelling of the face, lips, arms, or legs
• rash or hives

Antibody formation. Your body can also make antibodies, called “inhibitors,” against coagulation Factor X, which may stop this medication from working properly. Your healthcare provider may give you blood tests to check for inhibitors.

Infections that may be transmitted from this medication. Coagulation Factor X is made from human blood and may contain infectious agents, such as viruses, that can be transmitted while using this medication and cause diseases. Report any symptom that concerns you to your healthcare provider.

You should not receive this medication if you are allergic (hypersensitive) to any of the ingredients in coagulation Factor X.

Serious side effects have been reported with coagulation Factor X. See the “Coagulation Factor X Precautions” section.

Common side effects of coagulation Factor X include the following:

• redness and pain at the injection site
• fatigue
• back pain

This is not a complete list of coagulation Factor X side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• anticoagulant (blood thinner) medications that are Factor Xa inhibitors, such as fondaparinux (Arixtra), apixaban (Eliquis), edoxaban (Savaysa), or rivaroxaban (Xarelto)

This is not a complete list of coagulation Factor X drug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant.

No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Coagulation Factor X should be given to a pregnant woman only if clearly needed.

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if this medication crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using coagulation Factor X.