Clomipramine

Clomipramine is a prescription medication used to treat symptoms of obsessive-compulsive disorder (OCD). Clomipramine belongs to a class of drugs called tricyclic antidepressants. These work by increasing the amount of serotonin in your brain, a naturally occurring chemical that is involved in mental balance.

This medication comes in an oral (by mouth) capsule form and is usually taken once a day, at bedtime. At the beginning of treatment with clomipramine, it is usually given in divided doses, with food.

Common side effects of clomipramine include nausea, dry mouth, and constipation.

Clomipramine can also cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how clomipramine affects you.

Clomipramine is a prescription medication used to treat symptoms of obsessive-compulsive disorder (OCD), a mental illness that causes people to have consistent worry and stressful thoughts that create a need to perform compulsive behaviors repeatedly. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

• other medications you are taking
• how you respond to this medication
• your weight
• your age

The initial recommended dose of clomipramine is 25 mg daily. The dose should be gradually increased, as tolerated, to approximately 100 mg daily during the first 2 weeks. The maximum recommended dose of clomipramine is 250 mg daily.

Initially, the medication should be divided into 3 doses and taken with meals. After the dose has been increased, the total daily dose may be given once daily, at bedtime.

Suicidality and Antidepressant Drugs

Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of clomipramine hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Clomipramine hydrochloride is not approved for use in pediatric patients except for patients with obsessive compulsive disorder (OCD).

Serious side effects have been reported with clomipramine, including the following:

• uncontrollable shaking
• fast, irregular, or pounding heartbeat
• difficulty urinating or loss of bladder control
• believing things that are not true
• hallucinations
• difficulty breathing or fast breathing
• severe muscle stiffness
• unusual tiredness or weakness
• sore throat, fever, and other signs of infection

Clomipramine can also cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how clomipramine affects you.

Do not take clomipramine if you:

• are allergic to clomipramine or to any of its ingredients
• have taken a monoamine oxidase inhibitor in the last 14 days
• are taking linezolid
• are taking methylene blue
• have recently had a heart attack

Serious side effects have been reported with clomipramine. See the "Clomipramine Precautions" section.

Common side effects of clomipramine include the following:

• dry mouth
• constipation
• nausea
• vomiting
• diarrhea
• dyspepsia (indigestion)
• drowsiness
• dizziness
• nervousness
• headache
• changes in weight or eating habits
• changes in sexual desire

This is not a complete list of clomipramine side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate)
• anticoagulants ("blood thinners") such as warfarin (Coumadin, Jantoven)
• benztropine (Cogentin)
• cimetidine (Tagamet)
• clonidine (Catapres)
• dicyclomine (Bentyl)
• digoxin (Lanoxin)
• disulfiram
• flecainide (Tambocor)
• guanethidine (Ismelin)
• haloperidol (Haldol)
• levodopa (Sinemet, Dopar)
• linezolid (Zyvox)
• medications for nausea, dizziness, or mental illness
• methylene blue
• methylphenidate (Concerta, Metadate, Ritalin)
• oral contraceptives
• phenobarbital
• phenytoin
• propafenone (Rythmol)
• quinidine
• secobarbital (Seconal)
• sedatives
• selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem), sertraline (Zoloft), and paroxetine (Paxil)
• tranquilizers
• trihexyphenidyl (Artane)

This is not a complete list of clomipramine drug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if yo are pregnant or plan to become pregnant. 

The FDA categorizes medication based on safety for use during pregnancy. Five categories - A, B, C, D, and X - are used to classify the possibel risks to an unborn baby when a medication is taken during pregnancy.

Clomipramine falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Tell your doctor if you are breastfeeding or plan to breastfeed.

Clomipramine has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from clomipramine, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.