Cinryze

Cinryze is a prescription medication used to prevent angioedema attacks in adults and adolescents with hereditary angioedema (HAE). Cinryze belongs to a class of medications called recombinant serine proteinase inhibitors. These work to prevent angioedema attacks by reducing the permeability of certain small blood vessels.

This medication is available in an injectable form to be given directly into a vein and is typically given every 3 or 4 days.

Common side effects of Cinryze include headache, nausea, and rash.

Cinryze can also cause dizziness. Do not drive or operate heavy machinery until you know how Cinryze affects you.

Cinryze is a prescription medication used to prevent angioedema attacks in adults and adolescents with hereditary angioedema (HAE).

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your age

The recommended dose of Cinryze to prevent angioedema attacks in adults and adolescents with hereditary angioedema (HAE) is 1,000 International Units (IU) injected into a vein (intravenously) every 3 or 4 days.

Serious side effects have been reported with Cinryze including the following:

• Serious allergic reactions. The signs and symptoms of serious allergic reactions may include the appearance of hives, skin redness, itching, tightness of the chest, and/or wheezing experienced during or after injection of Cinryze. If you experience any of these symptoms, discontinue use immediately and seek emergency medical attention.
• Blood clots. Serious blood clots have been reported in patients taking the recommended doses of Cinryze. Risk factors may include presence of a permanent catheter, prior history of blood clots, heart disease, use of oral contraceptives, morbid obesity, and immobility. Benefits of Cinryze should be weighed against the risks of blood clots in people with underlying risk factors. Consult with your physician about the risks for developing serious blood clots before beginning treatment with Cinryze.
• Transmission of infectious agents. Because Cinryze is made from human blood products, it may carry a risk of transmitting infectious agents including viruses like HIV. Consult with your physician about this risk before beginning treatment with Cinryze.

Cinryze can also cause dizziness. Do not drive or operate heavy machinery until you know how Cinryze affects you.

Do not take Cinryze if you are allergic to Cinryze or to any of its ingredients.

Serious side effects have been reported with Cinryze. See the “Cinryze Precautions” section.

Common side effects of Cinryze include the following:

• headache
• nausea
• rash
• fever
• dizziness
• injection site pain

This is not a complete list of Cinryze side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• alteplase
• anistreplase
• bazedoxifene
• chlorotrianisene
• conjugated estrogens
• danazol
• darbepoetin alfa
• dehydroepiandrosterone
• desogestrel
• dienestrol
• dienogest
• diethylstilbestrol
• drospirenone
• epoetin alfa
• epoetin beta-methoxy polyethylene glycol
• esterified estrogens
• estradiol
• estrone
• estropipate
• ethinyl estradiol
• fluoxymesterone
• lenalidomide
• mestranol
• methyltestosterone
• nandrolone
• ospemifene
• oxandrolone
• oxymetholone
• peginesatide
• pomalidomide
• quinestrol
• raloxifene
• reteplase
• stanozolol
• streptokinase
• tamoxifen
• tenecteplase
• testolactone
• testosterone
• thalidomide
• toremifene
• urokinase            

This is not a complete list of Cinryze drug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Cinryze falls into category C. There are no well-controlled studies that have been done in pregnant women. Cinryze should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Cinryze crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Cinryze.