Condition

Graves disease

Graves' disease is an autoimmune disease that affects the thyroid, causing hyperthyroidism.

Endocrine

Overview

Graves' disease is an autoimmune disease that affects the thyroid, causing hyperthyroidism. The immune system makes antibodies that trigger the thyroid to make more thyroid hormone than your body needs. An overactive thyroid increases the body's metabolic rate,

Common symptoms of an overactive thyroid include goiter (an enlarged thyroid), trouble sleeping, nervousness, irritability, heat sensitivity, and unexplained weight loss.

With Graves' disease, the immune system makes antibodies that act like TSH, which triggers the thyroid to make more thyroid hormone than your body needs. This is called an overactive thyroid or hyperthyroidism. An overactive thyroid causes every function of the body to speed up, such as heart rate and the rate your body turns food into energy. Many factors are thought to play a role in getting Graves' disease including genetics, gender or sex hormones, severe emotional stress or trauma, pregnancy, and infection.

Graves' disease treatments include medications, radioactive iodine therapy, and surgery. Methimazole and Propylthiouracil act on the thyroid from making too much thyroid hormone. Radioactive iodine destroys thyroid cells so that less thyroid hormone is made. Surgical removal of the thyroid is another treatment option. 

Symptoms

  • Goiter (enlarged thyroid)
  • Trouble sleeping
  • Irritability or nervousness
  • Heat sensitivity, increased sweating
  • Hand tremors
  • Rapid heartbeat
  • Thinning of skin or fine, brittle hair
  • Frequent bowel movements
  • Weight loss without dieting
  • Fatigue or muscle weakness
  • Lighter menstrual flow and less frequent periods
  • Problems getting pregnant
  • Eye changes. For some people with Graves' disease, the tissue behind the eyes becomes inflamed and swells. This can cause bulging or discomfort in one or both eyes. Sometimes it affects vision. Eye symptoms can occur before, at the same time, or after other symptoms of Graves' disease begin. It may rarely occur in people with normal thyroid function. We do not know why these eye problems occur. They are more common in people who smoke, and smoking makes eye symptoms worse. Eye problems often get better without treatment.
  • Reddening and thickening of the skin, often on the shins and tops of the feet. This rare skin problem is not serious and is usually painless. Most people with this skin problem also have eye problems from Graves' disease.

When to get help

See your doctor for a racing heartbeat, unexplained weight loss, nervousness, heat intolerance, or an enlarged thyroid (goiter). Seek emergency care for a very fast or irregular heartbeat, high fever, or confusion.

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All information on this site is provided “as-is” for informational purposes only and is not a substitute for medical advice or treatment. You should consult with a medical professional if you have any questions about your health.